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CONCISE REVIEW: β CELL REPLACEMENT THERAPIES IN TREATMENT OF DIABETES MELLITUS

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dc.contributor.authorErgün, Büşra
dc.contributor.authorSomuncu, Özge Sezin
dc.contributor.authorÇelik, Umay
dc.contributor.authorArpalı, Emre
dc.contributor.institutionAcıbadem Mehmet Ali Aydınlar Üniversitesi
dc.contributor.institutionBahçeşehir Üniversitesi
dc.contributor.institutionBahçeşehir Üniversitesi
dc.contributor.institutionKoç Üniversitesi
dc.date.accessioned2025-09-20T20:00:03Z
dc.date.issued2019
dc.date.submitted13.08.2020
dc.description.abstractGlikoz alımının metabolik oranı, genellikle adacık hücrelerini ve insüline duyarlı dokuları kapsayan bir geri bildirim mekanizması ile kontrol edilir. İnsülin varlığında β hücreleri insülin üretimini artırarak standart glikoz toleransını korurlar. βhücre disfonksiyonunda kalıtsal bileşenlerin etkileri yüksek olsa da, çevresel değişikliklerin de önemli bir rol oynadığı gösterilmiştir. Güncel araştırma yöntemleri, insülin direnci ve β-hücre disfonksiyonunun oluşmasında heksozların, amino asitlerin ve yağ asitlerinin etkilerinin varlığını göstermekle birlikte, hücre fonksiyonunun aşamalı kaybını yavaşlatmak için daha etkili tedavilerin gerekliliğini de göstermektedir. Klinik araştırmalardan elde edilen sonuçlar diyabetin durdurulması ve tedavi edilmesi ve bu müdahalelerin olumsuz özelliklerinden bazıları ile ilgili önemli bilgiler sunmaktadır. Birincil adacık hücreleri ile aynı şekilde çalışan pankreatik endokrin hücrelerinin yeterli sayıda üretilmesi, iyileştirilmesi için hücre tedavilerinin genişletilmesi büyük öneme sahiptir. Bu derlemede, adacık ve pankreas transplantasyonlarından başlayıp kök hücre teknolojisi ve biyomühendislik odaklı yeni tedavi tekniklerinin incelenmesine odaklandık. Adacık hücre kaybı için tedavi perspektiflerinin kapsamlı ve ayrıntılı bir açıklamasını yapmayı amaçladık. Dolayısıyla bu inceleme, mevcut tedavileri ve geleceğe dayalı tedavileri aydınlatmak için açıklayıcı bir potansiyel taşımaktadır.
dc.identifier.doi10.23902/trkjnat.469530
dc.identifier.endpage54
dc.identifier.issn2147-0294
dc.identifier.issn2528-9691
dc.identifier.issueKök Hücre
dc.identifier.startpage45
dc.identifier.urihttps://hdl.handle.net/20.500.14719/5268
dc.identifier.volume20
dc.language.isoen
dc.relation.journalTrakya University Journal of Natural Sciences
dc.subjectMühendislik
dc.subjectBiyotıp
dc.subjectEndokrinoloji ve Metabolizma
dc.subjectHücre Biyolojisi
dc.titleCONCISE REVIEW: β CELL REPLACEMENT THERAPIES IN TREATMENT OF DIABETES MELLITUS
dc.typeReview
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