Publication:
THE EFFECT OF ANTI-INFLAMMATORY, ANTIOXIDATIVE, AND NEUROPROTECTIVE CHARACTERISTICS OF ALOPERINE ON EXPERIMENTAL ACUTE SPINAL CORD INJURY IN A RAT MODEL

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dc.contributor.authorYerlikaya, Fatma Hümeyra
dc.contributor.authorCüce, Gökhan
dc.contributor.authorAraç, Densel
dc.contributor.authorGülsever, Cafer İkbal
dc.contributor.authorYıldız, Mehmet Zeki
dc.contributor.authorSönmez, Evren
dc.contributor.authorKocaoğullar, Yalçın
dc.contributor.institutionSelçuk Üniversitesi
dc.contributor.institutionNecmettin Erbakan Üniversitesi
dc.contributor.institutionNecmettin Erbakan Üniversitesi
dc.contributor.institutionİstanbul Üniversitesi
dc.contributor.institutionBahçeşehir Üniversitesi
dc.contributor.institutionSağlık Bilimleri Üniversitesi
dc.contributor.institutionNecmettin Erbakan Üniversitesi
dc.date.accessioned2025-09-20T19:54:32Z
dc.date.issued2024
dc.date.submitted27.09.2024
dc.description.abstractObjective: Spinal cord injury (SCI) disrupts nerve axons with devastating neurological consequences. However, there is no effective clinical treatment. The purpose of this study was to investigate the effects of the anti-inflammatory, antioxidative, and neuroprotective characteristics of alverine on traumatic spinal injury in a rat model. Materials and Methods: A total of 36 Wistar albino rats, each weighing 300-400 g, were divided into four treatment groups. In Group 1 (sham/control, n=9), only laminectomy was performed. In Group 2 (SCI, n=9), SCI was simulated after laminectomy. In Group 3 (SCI + saline, n=9), physiological saline solution was injected after SCI was induced. In Group 4 (SCI + aloperine), aloperine was administered after SCI was induced. SCI was established using the weight drop technique after laminectomy. Results: Neurological examination scores were significantly better in the aloperine-treated group than in Groups 2 and 3. SCI significantly increased serum and spinal cord tissue glutathione peroxidase, total oxidant status, 8-hydroxiguanosine, and interleukin-6 levels. These levels were successfully reduced with alverine administration. Interleukin-10 and total antioxidant status levels also decreased with alverine administration. Increased histopathological spinal cord damage score and apoptotic index in Groups 2 and 3 were significantly decreased in Group 4. Conclusion: Aloperine reduced apoptosis and increased anti-inflammatory and antioxidative mediator levels, which protected the SCI rat model against secondary nerve injury.
dc.identifier.doi10.4274/jtss.galenos.2024.63644
dc.identifier.endpage18
dc.identifier.issn2147-5903
dc.identifier.issue1
dc.identifier.startpage13
dc.identifier.urihttps://hdl.handle.net/20.500.14719/4384
dc.identifier.volume35
dc.language.isoen
dc.relation.journalJournal of Turkish Spinal Surgery
dc.subjectTıbbi Araştırmalar Deneysel
dc.titleTHE EFFECT OF ANTI-INFLAMMATORY, ANTIOXIDATIVE, AND NEUROPROTECTIVE CHARACTERISTICS OF ALOPERINE ON EXPERIMENTAL ACUTE SPINAL CORD INJURY IN A RAT MODEL
dc.typeResearch Article
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