Comparison of the Algan Hemostatic Agent with Floseal in Rat Liver \rLaceration Bleeding Model

Abstract

Objective: Major vascular injury is one of the most important causes of death after trauma. The effective \rand speedy control of the hemorrhage is crucial in reducing deaths. Many products are used for this purpose. \rToday, however, an ideal product has not yet been produced and there is a strong demand for such effective \rhemostatic products. The aim of this study is to compare the efficacy of Algan hemostatic agent with Floseal \rin the liver laceration model in rats.\rMaterials and Methods: A total of 28 rats were used in the study. Rats were divided into 4 groups, each \rconsisting of 7 rats. Experimental liver laceration was established. In the control group, saline-impregnated \rgauze was applied. Algan hemostatic agent-impregnated sponge, Algan hemostatic agent powder, and Floseal \rgel were applied to the experimental groups.\rResults: There was no difference in bleeding control among the Algan hemostatic agent powder, Algan \rhemostatic agent-impregnated sponge, and Floseal. When compared to the control group, Algan hemostatic \ragent powder, Algan hemostatic agent-impregnated sponge, and Floseal were found to be very effective in \rbleeding control, respectively (P=.001, .012, and .002), in the experimental groups.\rConclusion: This study showed that the properties of both Algan hemostatic agent powder and Algan \rhemostatic agent-impregnated sponge for controlling bleeding are similar to Floseal. Considering other characteristics such as Algan hemostatic agent’s naturalness, easy applicability, and low cost, Algan hemostatic \ragent has been a promising effective hemostatic agent.