Serum renalase and cerebellin levels in acute central serous chorioretinopathy

Abstract

Aim: To compare the blood renalase and cerebellin-1 levels of acute central serous chorioretinopathy(CSC) patients with healthy subjects.Method: A total of 33 eyes with acute naïve CSC (less than 2 months duration) and 31 healthysubjects were enrolled in this study. Idiopathic CSC was diagnosed based on the presence of a serousdetachment of the neurosensory retina involving the macula that was confirmed using opticalcoherence tomography and leakage at the retinal pigment epithelium level using fluoresceinangiography. Blood samples were collected and centrifuged at 4000 g for 10 minutes. The serumsamples were collected and stored at -80 °C until required for analysis. Serum renalase and cerebellin-1 levels were measured using an ELISA kit.Results: In CSC group 11 patients were female and 22 patients were male. In control group 10participants were female and 20 were male. The sex was similar between groups. Mean age in CSCgroup was 41, 04±5, 94, in control group was 40, 67±6, 53. Mean ages were similar between groups.Mean renalase levels in CSC group was 27, 19±14, 01 ng/ml and in control group was 19, 12±15, 57ng/mL. Mean renalase level was higher in CSC group. Mean cerebellin levels were 57, 76±29, 72pg/mL and 52, 50±29, 25 pg/mL in CSC and in control groups, respectively. Mean cerebellin levelswere similar in groups.Conclusion: Comparing with healthy subjects serum renalase levels were higher and cerebellin-1levels were similar in CSC patients.