Publication:
Effects of 4% Icodextrin on Experimental Spinal Epidural Fibrosis

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dc.contributor.authorAntar, Veysel
dc.contributor.authorÇınar, Nilgün
dc.contributor.authorAkdemir, Hidayet
dc.contributor.authorKaraoğlan, Alper
dc.contributor.authorKelten, Bilal
dc.contributor.authorKarancı, Türker
dc.contributor.authorKara Yalçınkaya, Zeynep Mine
dc.contributor.authorMidi, Ahmet
dc.contributor.institutionT.C. Sağlık Bakanlığı
dc.contributor.institutionMaltepe Üniversitesi
dc.contributor.institutionT.C. Sağlık Bakanlığı
dc.contributor.institutionMaltepe Üniversitesi
dc.contributor.institutionMaltepe Üniversitesi
dc.contributor.institutionT.C. Sağlık Bakanlığı
dc.contributor.institutionT.C. Sağlık Bakanlığı
dc.contributor.institutionBahçeşehir Üniversitesi
dc.date.accessioned2025-09-20T20:02:11Z
dc.date.issued2017
dc.date.submitted29.07.2022
dc.description.abstractAIM: The aim of this experimental study was to investigate whether spinal epidural 4% glucose polymer solution is effective in the prevention of postoperative fibrosis. MATERIAL and METhODS: Twenty eight adult Wistar albino rats were randomly divided into two equal groups, including treatment and control. Both groups underwent L1 vertebral total laminectomy to expose the dura. Topical treatment group received 4% icodextrin. Four weeks later, epidural fibrosis was examined in both groups histologically, biochemically and macroscopically. RESuLTS: Topical use of 4% icodextrin prevented significantly epidural fibrosis following the laminectomy operation. COnCLuSIOn: Topical 4% icodextrin application inhibits postoperative epidural fibrosis with various mechanisms and prevents adhesions by playing barrier role between tissue surfaces through flotation. Our study is first to present evidence of experimental epidural fibrosis prevention with 4% icodextrin.
dc.identifier.endpage271
dc.identifier.issn1019-5149
dc.identifier.issue2
dc.identifier.startpage265
dc.identifier.urihttps://hdl.handle.net/20.500.14719/5612
dc.identifier.volume27
dc.language.isoen
dc.relation.journalTurkish Neurosurgery
dc.subjectNörolojik Bilimler
dc.subjectCerrahi
dc.titleEffects of 4% Icodextrin on Experimental Spinal Epidural Fibrosis
dc.typeResearch Article
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