Models for Wound Healing and Scarring

Abstract

Cutaneous wound healing represents a vital response which repairs various types of injury all over the body. Wound healing is designed to restore physiological and anatomical functions. Understanding mechanisms of wound healing and its complications is vital to patient care in all fields of medicine such as trauma, burns, obesity, diabetes and cancer. A variety of wound healing/scarring models have been developed: preclinical models that include in vitro cell culture and tissue engineered models, in vivo animal models, and clinical human volunteer/patient models. All these models have their own advantages and disadvantages. The in vitro and in vivo models of wound healing/scarring are intended to study mechanisms of wound healing and its complications, underlying cellular pathways, preventive and therapeutic alternatives. The important factor in choosing the ideal model is to determine which type of wound/scarring and wound healing stage are planned to be investigated. © 2020 Elsevier B.V., All rights reserved.